Dogoteka LactoAdapt supplements for dogs and cats to maintain the normal balance of intestinal flora, N60

LactoAdapt Complementary feed for dogs and cats, designed to maintain the normal balance of intestinal flora, consisting of pre- and probiotics. INDICATIONS: LactoAdapt has a positive effect on the balance of intestinal flora and is therefore useful in the following cases: - using antibiotics - by changing the diet - nutritional disorders - poisoning - during periods of stress - seasonal changes PREBIOTICS THE TRIO OF PREBIOTIC FIBERS: - FRUIT OLIGOSACCHARIDES (FOS) - INULIN - MANNANO OLIGOSACCHARIDES (MOS) from brewer's yeast FOS, MOS and INULIN are dietary fibres, i.e. i.e. indigestible carbohydrates, undoubtedly important in both human and animal nutrition. Chemically, FOS and inulin are fructans (carbohydrates made up of repeating fructose units) with a short chain (FOS) and a slightly longer chain (INULIN), and are particularly abundant in foods such as chicory and Jerusalem artichoke. MOS are always dietary fibers, but are composed of mannose repeats and are mainly derived from yeast walls. All three substances act as prebiotics, i.e. i.e. they can be beneficial to health by regulating the gut microbiota, i.e. i.e. a collection of millions of microorganisms characteristic of the intestinal tract of various mammals. These microorganisms have a positive and vital effect on the health of the host. ((Suchodolski, 2011)). Indeed, there are several studies that consistently emphasize the symbiosis between health maintenance and gut microbiota balance. How do prebiotic fibers positively affect the microbiota? Humans and other mammals, including dogs and cats, do not have all the enzymes in their intestines to break down plant fibers (such as fructooligosaccharides and inulin) (Flint HJ, 2012), so when they enter the small intestine, they are not digested and are fermented by the bacteria of the colonic microbiota, thus having a positive effect on the abundance of certain groups of beneficial bacteria (such as Lactobacillus and Bifidobacterium); this effect positively affects many functions, e.g. intestinal motility, cell integrity and biochemical networks of microorganisms. (Scott KP, 2015). Several studies have shown that the integration of fructooligosaccharides into the diet of dogs improves the absorption of various mineral substances and increases the number of Bifidobacteria, one of the beneficial microorganisms that actually live in the intestines of both humans and dogs and play an important role in the modulation of the immune system and digestive functions as well (Carlo Pinna1, 2018). However, the mechanism of action of MOS prebiotics seems to be different - various studies emphasize their ability to selectively bind to receptors on the intestinal wall, making them inaccessible to pathogenic bacteria, which promotes the growth of good bacteria. PROBIOTICS: ENTEROCOCUS FAECIUM DSM 10663/NCIMB 10415 (35 X 10^9 CFU/g) What are probiotics? In the feed sector, these are so-called zootechnical additives that stabilize the intestinal flora, i.e. i.e. microorganisms that, when given to animals, have a positive effect on their intestinal flora; (Europeo, 2003) they can actually colonize the gut of the host animal, giving it a beneficial effect. The attachment of a probiotic microorganism to the host's intestinal mucosa is considered the most important stage for colonization and further interaction with the host's epithelium and its immune system. (Mohsen Hanifeh, 2021). In fact, both pathogenic and commensal microorganisms (Commensals are microorganisms that live on any body surface or near the mucous membrane without harming the health of humans/animals) secrete various adhesin molecules on their surface that allow them to attach to various surfaces of the host. For this reason, when selecting strains of microorganisms with a probiotic effect, they must have a high ability to attach to the intestine. Some studies have shown that this ability is related to host specificity; therefore, to be effective as a probiotic, the bacterial species should be of host intestinal origin, and Enterococcus faecium DSM 10663/NCIMB 10415 used in LactoAdapt has this characteristic. Probiotics can improve mucosal health through several mechanisms, including the production of short-chain fatty acids (SCFA), antimicrobial agents, modulation of the immune response, competitive elimination of pathogenic bacteria by interfering with their adhesion to the intestinal mucosa, and improvement of epithelial barrier functions. INACTIVATED BACTERIA (LACTOBACILLUS HELVETICUS HA 122 (ex ACIDOPHILUS HA122), LACTOBACILLUS PARACASEI HA108, BIFIDOBACTERIUM BIFIDUM: Inactivated microorganisms, also called tindalized (Tyndalized is a sterilization method that destroys all phases of microbial development, including spores.), treated with a certain thermal method that inactivates them, so they can no longer Therefore, their activity is not related to the possibility of creating new offspring and thus colonizing the intestine, but to the fact that they form the basis on which a suitable substrate for the colonization of the symbiotic flora is restored at the intestinal level. Sweet carob or sweet bean tree (Ceratonia siliqua L.) is an evergreen tree of the legume family that grows in arid and semi-arid regions of the Mediterranean basin. Despite their high sugar content, their pods are rich in insoluble fiber and micronutrients, including phenolic compounds, inositols (mainly d-pinitol) and vitamins. (Aristea Gioxari 1, 2022) YANG®: This is a blend of inactivated yeasts, specifically Saccharomyces cerevisiae (commonly known as brewer's yeast) and Cyberlindnera jadinii. Yeasts are unicellular eukaryotic organisms that belong to the fungi kingdom. Brewer's yeast (Saccharomyces cerevisiae) is particularly used in animal nutrition due to its nutritional value, as it is rich in valuable macronutrients such as protein, as well as micronutrients such as selenium and chromium, B vitamins and many other substances beneficial to health. This effect is primarily due to the abundance of nutrients. Cyberlindnera jadinii is also a widely used yeast for its nutritional value as it is also rich in protein and vitamins. PETMOD® NUCLEOTIDES FROM BREWER'S YEAST Nucleotides are the repeating elements that make up nucleic acids (DNA and RNA). They consist of three components: a nitrogenous base (purine or pyrimidine), a 5-carbon sugar that forms a nucleoside with the nitrogenous base, and one or more phosphate groups. Some studies conducted with fish have shown that dietary nucleotides have a beneficial effect on the intestine, promoting its growth and development. (Toshimasa Tsujinaka MD, 1999) For this reason, there is a growing demand for adding nucleotides to pet food, with the ultimate goal of contributing to normal immune function and intestinal health in pets. (Natalia Russo1, Nucleotide inclusion in pet food: effect of heat treatment, 2019) BANANA FLOUR Banana is a very popular fruit in the world market and is used as a staple food in many countries. It is consumed raw or processed, and also as a functional ingredient in various food products. Bananas contain several bioactive compounds such as phenols, carotenoids, biogenic amines and phytosterols that have many positive effects on health and well-being. Many of these compounds have antioxidant effects, protecting the body from oxidative stress. (Balwinder Singh a, 2015) Some studies have shown that the polyphenolic component, specifically flavonoids, in addition to its antioxidant effect, also plays a positive role at the gastric level. 1 tablet contains: Fructooligosaccharides FOS 50 mg Inulin 50 mg Mannanoligosaccharides MOS 75 mg Sweet carob flour 25 mg Yeast from inactivated Saccharomyces cerevisiae and Cyberlindnera jadinii 250 mg Yeast products (Saccharomyces cerevisiae nucleotides) 5 mg Banana flour 75 mg Inactivated bacteria and their parts (Lactobacillus helveticus HA 122) 10 mg Inactivated bacteria and their parts (Lactobacillus paracasei HA 108) 10 mg Inactivated bacteria and their parts (Bifidobacterium bifidum SGB02) 2.5 mg Enterococcus faecium DSM 10663/ NCIMB 10415 35 x 106 UFC Dosage and method of use: 0-10 kg - 1 tablet 10-20 kg - 2 tablets 20-30 kg - 3 tablets over 30 kg - 4 tablets Give the tablets together with the daily feed portion or directly into the animal's mouth. It is recommended to use the product without breaks. Packaging: LactoAdapt® Additional feed for dogs and cats, useful for maintaining the correct intestinal bacterial flora, 15 tablets of 1 g each. LactoAdapt® Supplemental feed for dogs and cats, useful for maintaining regular intestinal bacterial flora, 60 tablets of 1 g each.